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Gritters have been out in force and an emergency homeless shelter has opened in Brighton as temperatures plummet, with forecasts of heavy snow.
The city council has gritted roads during the week and has urged people to check on vulnerable neighbours. In West Sussex, Gatwick Airport urged passengers to check with their airlines before travelling after weather warnings were issued across the UK.
Gatwick invested £8m in snow and ice clearance fleets after last winter. Forecasters said heavy snow was expected after dusk on Saturday.
The Met Office issued amber "be prepared" snow warnings for areas across the UK, including the South East. The region was bracing itself for 5-10cm (up to 4in) of snow.
Brighton and Hove City Council said it had invested in a new fleet of gritting vehicles this year and a motorised pavement gritter. The local authority also said it had increased the number of grit bins in the city.
The council said it would not be able to grit every road and pavement and would prioritise the routes that would help keep the city moving.
Brighton council opens an emergency homeless shelter if three consecutive nights of freezing temperatures are forecast. The council said its outreach team worked to make contact with as many homeless people as possible.
Heavy snow has brought disruption to many parts of Britain, with road closures and flight cancellations. Up to 16cm (6in) of snow fell in some areas, and icy conditions have prompted warnings from the Met Office.
The M25 was shut in both directions between junctions 23 and 25 after an accident overnight, while on the M40 about 100 vehicles were stranded. A third of flights from Heathrow have been cancelled and some trains and Tube services disrupted.
Snow fell over parts of Scotland, Wales, northern England and the Midlands on Saturday before sweeping down to London and East Anglia.
Church Fenton, in North Yorkshire, reported 16cm (6in) of snow. Rain or sleet is forecast once the snowfall eases on Sunday morning, but then clear skies will lead to widespread icy patches forming across much of England and Wales, the Met Office said, advising people to "be prepared".